Stability of racemic and chiral steady states in open and closed chemical systems
نویسندگان
چکیده
Josep M. Ribó and David Hochberg ∗ Departament de Qúımica Orgànica, Universitat de Barcelona, c. Mart́ı i Franquès 1, Barcelona, Spain Centro de Astrobioloǵıa (CSIC-INTA), Ctra. Ajalvir Km. 4, 28850 Torrejón de Ardoz, Madrid, Spain Abstract The stability properties of models of spontaneous mirror symmetry breaking in chemistry are characterized algebraically. The models considered here all derive either from the Frank model or from autocatalysis with limited enantioselectivity. Emphasis is given to identifying the critical parameter controlling the chiral symmetry breaking transition from racemic to chiral steady-state solutions. This parameter is identified in each case, and the constraints on the chemical rate constants determined from dynamic stability are derived.
منابع مشابه
Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector
The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector L-tartarate. The effect of extraction equilibrium time, buffer pH, organic solvents and length of alkyl chain of L-tartarate on the partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. The L-tartara...
متن کاملTemporary mirror symmetry breaking and chiral excursions in open and closed systems
The reversible Frank model is capable of amplifying the initial small statistical deviations from the idealized racemic composition. This temporary amplification can be interpreted as a chiral excursion in a dynamic phase space. It is well known that if the system is open to matter and energy exchange, a permanently chiral state can be reached asymptotically, while the final state is necessaril...
متن کاملTernary Phase Diagram Modeling of Chiral Medetomidine Salts Using NRTL-SAC Model
Experimental determination of solubility and ternary phase diagram of chiral compound are of tedious and time consuming tasks, and in many cases, there is not enough experimental data for different enantiomeric compositions to access the experimental ternary phase diagram. Using thermodynamic models with predictive capability, having less dependency on experimental data, affords a great advanta...
متن کاملEnantioselective Release Behavior of Ketoprofen Enantiomers from Alginate-metal Complexes, Monitored by Chiral HPLC
Alginate-metal complexes were prepared with divalent (Ca, Ba, Zn) and trivalent metals (Fe, Al) via congealing method in form of beads. Alginate mixed metals (Ca & Fe) complexes were also prepared by simultaneous and consecutive congealing. The studied beads were blank beads and racemic ketoprofen (KTP) loaded beads. Metal content was determined by atomic absorption spectroscopy and was 1.8% to...
متن کاملClosed- and Open-loop Deep Brain Stimulation: Methods, Challenges, Current and Future Aspects
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...
متن کامل